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DMG: A Nutrient for the New Millennium

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DMG, short for dimethylglycine, is a nutritional supplement that can provide wonderful positive benefits to humans and animals. Our bodies use DMG every day, even though we don't know it. Humans and animals produce DMG in small amounts, and it affects nearly every metabolic pathway within each cell of the body. At the end of this paper, I will include the more technical, scientific information for those intrepid individuals who wish to learn more.

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Here is what you need to know about DMG:

It provides useful building units for biosynthesis of vitamins, hormones, neurotransmitters, antibodies, nucleic acids and other metabolically active molecules. It can be helpful in virtually all species of animals, including dogs, cats, rabbits, ferrets, rodents, reptiles and birds.DMG is one of the nutrients found in the supplement, Immune and Digestive Support. Many veterinarians have discovered the unique and wonderful properties of this new supplement.

Laboratory and clinical research indicates that DMG supplementation can be used effectively as a nutritional adjunct to a number of health issues in pets.

These include:
Cardiovascular problems
Glucose metabolism
Autoimmune disorders
Allergies
Cancer/tumors
Liver diseases
Respiratory problems
Immune response deficiencies
Neurological disorders
Neurological disorders

Let’s look at many of the specific conditions that Immune and Digestive Support containing DMG may help your pets.

DMG for Seizuring Animals

Ferrets with Insulinoma

DMG increases the threshold for seizures and can reduce seizures in all types of animals. In some cases, if DMG is added to a seizuring animal’s therapy, it may decrease the amount of anticonvulsants required by an animal. This can be very beneficial for ferrets suffering from insulinoma, until the blood sugar issues are under control. Diet plays a huge role in helping stabilize a ferret suffering from insulinoma, and Young Again Ferret Food is one very positive step in improving the health of a ferret. In some cases, an insulinoma may present as a solitary tumor in the pancreas, but for most ferrets, the lesions are microscopic infiltrates, and surgery is not considered the best way to treat this condition. Some veterinarians recommend surgically removing approximately 1/3 of the pancreas, usually the tail of the pancreas, however, the pancreas is a delicate organ and surgery is not always beneficial.

DMG and the Immune System

It improves the immune response by increasing resistance to disease and infection.

It has antiviral and antibacterial properties. It can modulate the inflammatory response.

DMG and Tumors

A study was performed using mice and melanoma cells. Mice were injected with melanoma cells and those mice receiving DMG had fewer implantations of melanoma cells than the control group did. This study was performed at Baylor University.

It possesses anti-cancer activity and can prevent metastases (the spread of tumor cells). I routinely use DMG in all of my patients with any type of cancer. If it can help prevent the spread of tumors, then I am all for it.

DMG and Cardiac Disease

It aids in cardiovascular functions by reducing elevated cholesterol, blood pressure and triglyceride levels and improving circulation. Ferrets and cats with cardiac disease may benefit from the administration of DMG.

DMG and Diabetes in Cats

It improves glucose metabolism and for this reason, I recommend prescribing DMG for all diabetic cats, in addition to changing the cat’s food to Young Again Zero Carbohydrate Cat Food. Many diabetic animals will eventually develop cataracts in the lenses of the eyes, which can significantly decrease eyesight. When the cataracts are mature, the diabetic pet will eventually lose vision, except for being able to discern light and dark. DMG can retard cataract formation in diabetic animals.

DMG and IBD/IBS

According to literature studies, DMG helps with inflammation, circulation, healing and detoxification, all of which helps cats and dogs suffering from inflammatory bowel disease and inflammatory bowel syndrome. Young Again pet foods may help contribute to the resolution of issues related to chronic gastrointestinal problems in dogs and cats.

DMG and Cataracts

DMG is also an excellent adjunct to therapy for rabbits suffering from E. cuniculi, which is a microscopic protozoal organism that has an affinity for kidney tissue and the central nervous system (CNS). In addition to strengthening the immune system, DMG may also slow the formation of cataracts in the eyes of E. cuniculi infected rabbits.

DMG and Liver Disease

It aids in detoxification and enhances liver function. When administered, part of it will be converted to SAM-E, a nutrient helpful to the liver. Any cat suffering from hepatic lipidosis from not eating for one or several days may benefit from the administration of DMG.

DMG and Exercise

It improves oxygen utilization in the body and it removes lactic acid from muscle tissue. This makes DMG wonderful for athletic dogs. Lactic acid is what causes muscle cramps and pain after running. I know that many greyhound racers use DMG for their dogs. Many horse trainers believe it is helpful during training exercise.

It enhances energy levels, endurance and muscle metabolism.

It improves mental and physical performance.

It improves neurological function and mental clarity.

DMG use in Veterinary Medicine

DMG has been used by veterinarians and trainers in horses and dogs.

DMG is suggested for use in dogs, cats, horses and birds for performance and enhanced recovery from illness. It can be used therapeutically as an adjunct to traditional therapy for osteoarthritis, stress, seizures, allergies, heart disease, cancer, feline immunodeficiency virus (FIV), feline infectious peritonitis (FIP) and diabetes.

DMG has antifungal properties and helps fight bacterial and viral infections. It is converted to SAM-E in the body. It helps detoxify the liver. It decreases the inflammation associated with IBD (inflammatory bowel disease). It helps maintain glucose metabolism and can help slow the development of diabetic cataracts. DMG helps circulation and cardiovascular health.

It increases the threshold for seizures and I have personally used it to control seizures in many animals, including dogs, cats, Amazon parrots, lovebirds and many other animals. In many cases, DMG alone will control seizures, and in other cases, reduced amounts of anticonvulsants will be necessary (such as phenobarbital, Valium, Keppra or phenytoin). It can be used for many neurological problems in exotic animals, such as idiopathic seizures in red-lored Amazons and peach-faced lovebirds, E. cuniculi in rabbits, PDD in psittacines and hypoglycemic seizures in ferrets (resulting from insulinoma issues).

While the label recommendation is for once or twice a day dosing, this supplement is absorbed rapidly, so often I will recommend small, incremental doses during the day. Often to help control seizures, I find that more frequent dosing will control seizures (along with treating any underlying medical problems, such as infection, low blood glucose or even lead toxicosis) much better than just one or two doses per day. I recommend working with your veterinarian to adjust the DMG and/or anticonvulsant medications to best control seizures.

The Science of DMG

As promised, I am providing a bit of the science (including the jargon) about how DMG works. DMG is an adaptogen that works with other cofactors in the body to counteract the negative effects of stress, to promote healing and even to help prevent some degenerative diseases. Some of the things that it does are to decrease homocysteine levels (a risk factor for cardiovascular disease), increases oxygen utilization, modulates the immune response, aids in liver detoxification, regulates cholesterol and triglyceride levels, and increases energy levels. New research shows that DMG can function as an antioxidant and prevent free-radical damage. So, you can see how this nutrient can be a wonderful adjunct to traditional medical therapy for many different disease states.

DMG is found naturally in low levels in the body, and also in certain foods, such as meat (liver), beans, seeds and grains. It is considered an intermediary metabolite, meaning that it is rapidly broken down into other substances that the body needs. The body can produce small amounts of DMG from other nutrients, but supplementation can provide increased levels of DMG resulting in many healthful benefits for the body. DMG is built from the amino acid glycine and is physiologically active and important to cell metabolism. It provides methyl groups for modification, building and detoxifying many components in the body. Biochemically, it occupies a central position in the cell's metabolic pathway, so it can produce a wide range of biological effects in the body.

DMG and the Autistic Spectrum

While I have no personal experience with autistic children, there are many testimonials describing significant improvement in autistic children that are given DMG regularly. Apparently, many autistic children will become more verbal and communicative when taking DMG, and may become more interactive with family members. Again, I have no personal experience, but with children being diagnosed with any number of problems within the autism spectrum in almost epidemic proportions today, it is worth a look-see in case it can help a child that you might know. I don’t see how it can be detrimental. The same can be said for animals suffering from abnormal behaviors, such as pacing, repetitive behaviors, obsessive licking or those suffering from other unusual situations.

It improves verbal communications and social interactions in autistic individuals. While there isn’t any research in pets suffering from separation anxiety or other issues, DMG is certainly a “do no harm” addition to any medical and behavioral therapy.

Dosing DMG

DMG should be taken between meals, although it can be taken with food. DMG is broken down quickly and used by the body, so smaller, multiple doses are better than giving the entire dose all at once. The upper limit of dosing is extremely high; humans can take up to 6000 mg. per day without complications or risk of overdosage.

DMG comes in a liquid and the dosage is right on the label, and the dosage is also marked on the dropper which is included. Vetri-DMG Liquid is available for use in small animals and exotics. Each drop contains 5 mg of DMG.

According to the label dosing, the dosage for birds is: 1 drop per 100 grams body weight. This is given BID as a loading dose, for two weeks, then once a day. The liquid may also be used for dogs and cats:

Give dosage two times per day for the first two weeks, as a loading dosage, then give once a day, or for best results, divide dosage between a.m. and p.m. However, it is a very safe supplement and I will often tweak the dosage to accommodate the situation and provide the best support for the animal. Smaller, incremental doses are seemingly much more efficacious than one dose once a day.

If you are interested in reading more about DMG, there is a wonderful book entitled Building Wellness Through DMG (by Roger V. Kendall, Ph. D. with Adena Therrien, Freedom Press, 2003) that explains the science behind the supplement. The book discusses using DMG for lupus and other autoimmune disorders, respiratory disorders, cancer and autism, to name just a few. There are also many scientific papers that you can explore on-line, as well. The book discusses dosages for humans and animals with different conditions that might benefit from the administration of DMG.

DMG is available from several sources. Some nutrition and vitamin outlets sell DMG for humans in a powder, liquid or tablet/capsule form. I purchase mine as capsule from Now Foods, Bloomingdale, IL 60108, www.nowfoods.com. Another source is Best Naturals, NJ, www.shopbestnaturals.com.

DMG is available in tablets for small animals and exotics from Vetri-Science Labs, phone number: 800-882-9993. However, Vetri-Science Labs sells only to licensed veterinarians. For pet owners interested in purchasing single bottles, check the web, as we have seen it offered at Amazon.com.

Copyright © 2006 Margaret A. Wissman, D.V.M., D.A.B.V.P.
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For almost all character builds, knowing the best weapons in Skyrim for each type is going to be worthwhile. Some are available early on, too, through side quests or otherwise, which can be a massive help for playthroughs on harder difficulties, or for those with a burning desire to power through to Skyrim's late-game content.

Skyrim best weapons explained

Whether you're looking to tackle some of the more bizarre Daedric quests, or power-level your Smithing to craft Dragonbone and Daedric weapons, the weapon rankings below should be of some use to you, but before you dive in there are a couple of quick things to bear in mind about how we've structured it all:

• If you're looking to craft or enchant your weapons, be sure to check out our detailed guide to power-levelling Smithing and Enchanting skills to hit that level cap and craft the best weapons in the game as quickly as possible.
• An 'N/A' for Perk means you need to boost your Smithing past 100 with Alchemy to improve it beyond Flawless - specifically, you need to max your Smithing level to 100 and then use potions of Fortify Smithing to boost it beyond that, at which point the weapons in question, which don't benefit from any of the Smithing skill Perks, can then be improved beyond Flawless quality.
• The weapon sections below, excluding the Bows and Crossbows, are in order of lowest to highest damage and weight - so daggers first, with their low damage and low weight, moving ending with the heaviest and highest-damage Warhammers.
• For bows, higher weight means faster arrow travel speed, and normally a slower nocking speed.
• For one- and two-handed weapons, a higher weight means a slower swing speed, so for the most damage-per-second you'll want a combination of high base damage and low weight.
• If a weapon is listed as not enchantable, that will generally mean it's not disenchantable, either.
• We'll give a little extra context for our rankings in each section, but bear in mind we're considered damage-per-second here, too, so in many cases weight is just as important as raw damage!
• Unique items are marked with an asterisk * and we've briefly explained how to get them in that section's notes. Standard items like Daedric weapons, meanwhile, can always be found through either random loot or crafting.
• Stalhrim weapons' Frost Damage bonus is actually more powerful than it looks - the 'Chaos Damage' enchantment, which has a 50% chance of dealing 25 fire, frost, and shock damage simultaneously, is also boosted, making it an extremely potent choice for skilled enchanters.

The best Bows and Crossbows in Skyrim

A couple quick things to note about the bows and crossbows below:

• The Enhanced Dwarven Crossbow is part of the Dawnguard questline, and can only be obtained if you side with the Dawnguard over the Vampires. This specific type of crossbow is available to craft or buy after finding the schematic in one of the sis 'Ancient Technology' quests.
• Crossbows, whilst generally more powerful than bows in terms of damage, take a fair bit longer to fire each shot. They can also be equipped with exploding bolts of various damage types, too, which stack with any enchantments on the crossbow itself.
• Zephyr is found in the Dwemer ruin Arkngthamz during the Dawnguard quest 'Lost to the Ages'.
• The Nightingale Bow is found in the Inner Sanctum after you've defeated Arch-Curate Vythur in the Dawnguard quest 'Touching the Sky'.
• Note that with bows, there is generally a tradeoff between rate of fire and damage, and the choice depends on your playstyle. For stealth characters, higher damage bows like the Dragonbone, Daedric, and Nightingale bows are preferred, as they give you a greater chance of taking characters out in one hit from stealth and remaining undetected. For archers who expect to get in the mix a little more, attack speed is preferred, with bows like Zephyr and Auriel's bow, to help you maximise the stagger effect of your Perks, and deal sustainied damage as quickly as possible in extended combat.
• In the table, 'DPS' refers to the damage-per-second of the bow, taking into account both the bow's total speed to fully nock and fire and arrow, and it's base damage.

The best Daggers in Skyrim

Daggers have the highest attack speed and lowest base damage of all weapons in Skyrim, but that doesn't mean they should be ignored. In fact, for all One-Handed skill users, they can be essential:

• Dual-wielding means that the swing-speed of the fastest weapon is applied to both. So, for duel-wielders, equipping one of the below daggers like Mehrune's Razor, which has a tiny weight of just 3, will apply that same weight to a massive Daedric Mace when put in the other hand.
• Blade of Woe is acquired from either pickpocketing or killing Astrid of the Dark Brotherhood, or completeing the Dark Brotherhood quest 'With Friends like These'. If you pickpocket it from her before completing that quest, you can in fact obtain two copies of the weapon.
• Mehrunes Razor is a reward for completing the quest 'Pieces of the Past', if you opt to kill Silus Vesuius.

The best Swords in Skyrim

Swords are, as you'd expect, the most popular weapons in Skyrim thanks to their versatility and balance of both speed and damage. They're the fastest non-dagger one-handed weapons, but have lower damage than their mace and war axe counterparts.

• Windshear, firstly, benefits from appears to be a bug, whereby every attack with it will stagger your opponent - even dragons - rendering them completely unable to attack or reatreat as long as you continue to strike them with the right timing. It is only possible to obtain during the Dark Brotherhood quest 'Hail Sithis' on board The Katariah, where it's lodged, Excalibur-like, right at the very top of the ship's prow.
• Miraak's Sword is obtained by killing Miraak in the Dragonborn quest 'At the Summit of Apocrypha'.
• Chillrend can be found during the quest 'The Pursuit', inside the tunnels under Riftweald Manor in Riften, and can also be obtained by breaking into Riftwead Manor and accessing the tunnels from inside, after doing a spot of roof-hopping to get inside. Chillrend is levelled, too, meaning you get the stats we've detailed below at level 46 and over.
• Nightingale Blade is acquired as a reward for completing the Thieves Guild quest 'Hard Answers', and is also levelled, with the maximum stats we detail below gained if you're at level 46 or above.

The best War Axes in Skyrim

There aren't too many exciting options for those who prefer to bear a one-handed axe in Skyrim, but there are still one or two things to note:

• The Dawnguard Rune Axe is rated first because the 110 damage to undead can in fact be locked in by tempering the axe at a grindstone. It can also be improved with only the Steel Smithing Perk unlocked, making it an exceptional early-game choice. In certain situations, it's one of the best one-handed weapons you can get your hands on.
• The Rune Axe is acquired by completing the Dawnguard quest 'Lost Relic'.

The best Maces in Skyrim

• The Mace of Molag Bal is acquired from the Daedric quest 'The House of Horrors'.
• Molag Bal is only 1 damage lower than Dragonbone Mace but is much lighter, meaning a higher overall DPS - but this can be overcome with strong enchantments to the Dragonbone Mace.
• Same with Stalhrim, this time with the bonus enchantment damage making it a stronger choice overall.

The best Greatswords in Skyrim

Greatswords operate as the fastest, but lowest base damage weapons of the two-handed class. There are few unique ones of note, although the Bloodskal Blade provides an intriguing option.

• The Bloodska Blade is located next to Gratian Caerellius' corpse in Bloodskal Barrow, during the Dragonborn quest 'The Final Descent'.

The best Battleaxes in Skyrim

The middle tier of heavy weapons, the battleaxe class also plays home to one of the best weapons in the game, Wuuthrad.

• Wuuthrad is obtained during the Companions mission 'Glory of the Dead' - note that you'll need to place it in the hands of a statue of Ysgramor during the quest, but can be immediately removed after doing so.
• The HEadsman's Axe can be acquired from two people, Ahtar from Solitude, and the Imperial Headsman in the opening prisoner sequence. It can only be obtained from Ahtar, by their gaining him as a follwer and taking it from him for free, pickpocketing it from him, or killing him and looting his corpse.

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From visual upgrades, to console mods and levelling skills.

Want more help with Skyrim? Find out how to join every guild and faction, how to earn Gold fast, learning about XP and levelling to 100, max Crafting skills, max Warrior skills, max Thief skills and max Mage skills, how to get married, where to buy a house, how to start Dawnguard, Hearthfire and Dragonborn DLC expansions. If you're on PC, we have a list of console commands and cheats, and you can learn about the remastered version and how to install mods with our Skyrim guide. Finally, with Switch owners, we have Skyrim amiibo support explained to help unlock special Zelda-themed items.

The best Warhammers in Skyrim

The heaviest of heavy weapons, warhammers are the slowest to swing but deal the greatest amount of damage per hit.

• Volendrung is one of the Daedric artifacts, obtained for completing the Daedric quest 'The Cursed Tribe'.
• The Longhammer is acquired from the cave Liar's Retreat, southwest of Solitude. It's located next to the body of Rahd, it's former owner.

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